- Each film coated tablet of Vilmet   50 mg/500 mg contains:   Vildagliptin                                     50  mg
  Metformin hydrochloride             500 mg 
- Each film coated tablet of Vilmet   50 mg/850 mg contains:   Vildagliptin                                     50  mg
  Metformin hydrochloride             850  mg 
- Each film coated tablet of Vilmet   50 mg/1000 mg contains:   Vildagliptin                                     50  mg
  Metformin hydrochloride           1000  mg

Vilmet   is used to treat adult patients with type 2 diabetes. This type of diabetes is   also known as non-insulin-dependent diabetes mellitus. Vilmet   is used when
  diabetes cannot be controlled by diet and exercise alone and/or with other medicines   used to treat diabetes.

Vilmet® tablets are contrainticated in:-
- if you are allergic (hypersensitive) to vildagliptin, metformin or any of the other
  ingredients of this medicine .
- if you have uncontrolled diabetes, with, for example, severe hyperglycaemia (high   blood glucose), nausea, vomiting, diarrhoea, rapid weight loss, lactic acidosis  or 
  ketoacidosis. Ketoacidosis is a condition in which substances called ketone bodies   accumulate in the blood and which can lead to diabetic pre-coma. Symptoms include   stomach pain, fast and deep breathing, sleepiness or your breath developing an
  unusual fruity smell.
- if you have recently had a heart attack or if you have heart failure or serious
  problems with your blood circulation or difficulties in breathing which could be a
  sign of heart problems.
- if you have severely reduced kidney function.
- if you have a severe infection or are seriously dehydrated (have lost a lot of water
  from your body).
- if you are going to have a contrast x-ray (a specific type of x-ray involving an
  injectable dye).
- if you have liver problems.
- if you drink alcohol excessively .
- if you are breast-feeding .

Tell your doctor if you are taking, have recently taken or might take any other
  medicines. You may need more frequent blood glucose and kidney function tests, or
  ®your doctor may need to adjust the dosage of Vilmet  .
  It is especially important to mention to your doctor if you take the following:
- Glucocorticoids generally used to treat inflammation
- Beta-2 agonists generally used to treat respiratory disorders
- Other medicines used to treat diabetes
- Medicines which increase urine production (diuretics)
- Medicines used to treat pain and inflammation (NSAID and COX-2-inhibitors, such   as ibuprofen and celecoxib)
- Certain medicines for the treatment of high blood pressure (ACE inhibitors and   angiotensin II receptor antagonists)

- If you are pregnant, think you may be pregnant or are planning to have a baby, ask   your doctor for advice before taking this medicine. Your doctor will discuss with you
  the potential risk of taking Vilmet®   during pregnancy.
- Do not use Vilmet   if you are pregnant or breast-feeding

 Like all medicines, this medicine can cause side effects, although not everybody gets   them.
  You should stop taking Vilmet®   and see your doctor immediately if you experience   the following side effects:
- Lactic acidosis (very rare: may affect up to1 user in 10,000):
Vilmet®   may cause a very rare, but very serious side effect called lactic acidosis.
- Angioedema (rare: may affect up to 1 in 1,000 people): Symptoms include swollen   face, tongue or throat, difficulty swallowing, difficulty breathing, sudden onset of   rash or hives.
- Liver disease (hepatitis) (rare): Symptoms include yellow skin and eyes, nausea, loss   of appetite or dark-coloured urine.
- Inflammation of the pancreas (pancreatitis) (frequency not known): Symptoms   include severe and persistent pain in the abdomen (stomach area), which might reach   through to your back, as well as nausea and vomiting.

Some patients have experienced the following side effects while taking Vilmet 

- Always take this medicine exactly as your doctor has told you, Check with your
  doctor if you are not sure.
  The amount of Vilmet   that people have to take varies depending on their condition.   The recommended dose is one film-coated tablet of either 50 mg/850 mg or 50 
  mg/1000 mg taken twice a day.
  If you have reduced kidney function, your doctor may prescribe a lower dose.
  Also if you are taking an anti-diabetic medicine known as a sulphonylurea your
  doctor may prescribe a lower dose.
  Your doctor may prescribe this medicine alone or with certain other medicines that   lower the level of sugar in your blood.

Risk of lactic acidosis:
  Vilmet®   may cause a very rare, but very serious side effect called lactic acidosis,
  particularly if your kidneys are not working properly. The risk of developing lactic   acidosis is also increased with uncontrolled diabetes, serious infections, prolonged   fasting or alcohol intake, dehydration , liver problems and any medical conditions in   which a part of the body has a reduced supply of oxygen (such as acute severe heart   diseases).
  If any of the above apply to you, talk to your doctor for further instructions.
  Stop taking Vilmet®   for a short time if you have a condition that may be associated   with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea,   fever, exposure to heat or if you drink less fluid than normal.
  Stop taking Vilmet®   and contact a doctor or the nearest hospital immediately if you   experience some of the symptoms of lactic acidosis, as this condition may lead to   coma.Symptoms of lactic acidosis include:
  vomiting , stomach ache (abdominal pain),muscle cramps, a general feeling of not   being well with severe tiredness,difficulty in breathing and reduced body 
temperature
  and heartbeat. 
  A test to determine your liver function will be performed before the start of Vilmet®   treatment, at three-month intervals for the first year and periodically thereafter. This   is so those  signs of increased liver enzymes can be detected as early as possible.    During treatment with Vilmet®  , your doctor will check your kidney function at least
  once a year or more frequently if you are elderly and/or have worsening renal
  function.

- Vilmet®   50 mg/500 mg tablets: (Blister of 10 Tablets, Pack of 3 blisters).
- Vilmet   50 mg/850 mg tablets: (Blister of 5 Tablets, Pack of 4 blisters).
®
- Vilmet   50 mg/1000 mg tablets: (Blister of 10 Tablets, Pack of 3 blisters)

- Vilmet®   tablets store in a dry place at a temperature not exceeding 25°C.